If you’re thinking of the typical “gangsta” habit of holding a pistol sideways, we don’t.
Other than angled from the horizontal at a vertical or downward angle, there’s only one realistic answer…. The “Center-Axis-Relock” position:
This is a position for close-quarter combat that has been promoted in recent years, but is not widely accepted. It does offer considerable weapon-retention potential for close-combat shooting, and the slight angling of the weapon at such ranges doesn’t matter at all.
Trying to do this at longer distances would result in considerable “parallax” from the sight picture and the good chance of a total miss.